Acute leukemia may cause signs and symptoms that are similar to the flu. They come on suddenly within days or weeks.

Chronic leukemia often causes only a few symptoms or none at all. Signs and symptoms usually develop gradually. People with a chronic leukemia often complain that they just do not feel well. The disease is often found during a routine blood test.

Other health conditions can cause the same symptoms as leukemia. See your doctor if you have:

  • fatigue
  • a general feeling of discomfort or illness (called malaise)
  • loss of appetite
  • weight loss
  • fever
  • shortness of breath
  • paleness
  • rapid heartbeat (called palpitations)
  • weakness
  • dizziness
  • easy bruising
  • frequent or severe nose bleeds
  • bleeding gums
  • bleeding in the middle of a menstrual cycle or heavy menstrual flow
  • tiny, flat, red spots caused by bleeding just under the surface of the skin (called petechiae)
  • frequent infections in the lungs, urinary tract or gums or around the anus
  • frequent cold sores
  • vomiting
  • headache
  • sore throat
  • night sweats
  • bone or joint pain
  • enlarged lymph nodes in the neck, underarm, groin or above the collarbone
  • abdominal discomfort or feeling of fullness
  • vision problems
  • sores in the eyes
  • swelling of the testicles
  • chloroma – a collection of leukemia cells, or blasts, under the skin or in other parts of the body
  • leukemia cutis – appears as sores or as patches of any size that are usually pink or tan in colour
  • leukocytoclastic vasculitis – a condition that looks like an allergic reaction on the skin and usually causes sores on the hands and feet
  • Sweet’s syndrome, or acute febrile neutrophilic dermatosis – causes fever and painful sores that may appear anywhere on the body

In some cases, leukemia or its treatments can cause serious problems. These cancer-related emergencies need to be treated right away.

Tumour lysis syndrome can occur when chemotherapy is given to treat acute leukemia, but the cancer cells die quickly and the kidneys can’t remove the substances they release from the blood fast enough. Find out more about tumour lysis syndrome.

Superior vena cava syndrome (SVCS) may occur when too many leukemia cells develop in the thymus, causing it to get bigger and block the windpipe. SVCS may develop with acute lymphocytic leukemia (ALL). Find out more about superior vena cava syndrome.

Disseminated intravascular coagulation (DIC) is a condition where blood clots develop in the bloodstream and bleeding also occurs. DIC can develop more often with acute promyelocytic leukemia, but also with other subtypes of acute myelogenous leukemia (AML). Find out more about disseminated intravascular coagulation.

A rare, cancerous (malignant), green-coloured tumour that develops with myelogenous leukemia. It is formed by the buildup of abnormal blast cells (immature blood cells) that collect in soft tissue outside the bone marrow.

Chloromas develop most often in the bone, skin, lymph nodes, breast, ovary, meninges (membranes that cover and protect the brain or the spinal cord) and around the eye.

Also called extramedullary leukemia or granulocytic sarcoma.

Milk allergy is caused when the immune system (IS), which is there to protect us from bacteria and infections, mistakenly marks one or more of the 25 proteins found in milk to be harmful. Therefore it initiates a response to fight against the milk protein/s. The IS through specialised cells releases toxins, and it is these toxins that make persons with milk allergy to suffer the symptoms associated with food allergy. Milk is ranked among the top offenders for food allergies! In fact, many doctors, scientists, and health specialists recommend going dairy free as an initial test when a food allergy is suspected.

The symptoms of a milk protein allergy fall into 3 types of reactions:


  • Hives - red, itchy bumps on skin
  • Oedema - swelling of the skin, sometimes of the eyes and lips
  • Eczema - a dry and bumpy rash

Stomach and Intestinal Reactions:

  • Abdominal pain and bloating
  • Diarrhoea (usually very runny)
  • Vomiting
  • Gas/wind
  • Cramps

Nose, Throat and Lung Reactions:

  • Runny Nose
  • Sneezing
  • Watery and/or Itchy eyes
  • Coughing
  • Wheezing
  • Shortness of Breath

Milk allergy is often muddled with lactose intolerance. It is very important to understand the differences because it is only this way that you can help avoid the symptoms. When a person reacts to milk, the first assumption is that it is an allergy. However, things are the opposite, because while only around 2% of adults suffer from milk allergy the amount of people who have lactose intolerance are 50% or more! Lactose intolerance is caused by insufficient amount of enzymes to break down lactose, the sugar found in milk. For more details on lactose intolerance read here.

The table below shows the differences between lactose intolerance and milk allergy. Some symptoms may be common for both.

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I have been on multiple mental health medications whilst going through a long drawn out court case (7 years).

The medications per day included:

Lexapro (20 to 40mg past 7 years)

Mirtazapine (30mg past 7 years)

Sodium Valproate (1500mg, 1 year, 2013)

Lithium (150mg, taken once off Sodium Valproate, 6 months 2014)

Seroquel (750mg, 5 years, 2010 - 2014 )

Ritalin (50 mg per day in the past 6 months)

Lexapro is my last medication I am getting off now (under GP and psychiatrists supervisor / guidance). All other medications were weaned off of over a long period of time and in small increments.

I started going off Lexapro a two weeks ago (20 mg down to 10 mg), the first week I thought I was just getting my girlfriends flu.

Then I went from 10 mg to nothing.

This has been HELL!

Cold sores, mouth ulcers, lethargy, headaches, really bad insomnia, grumpy and unsociable.

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Medikamente gegen Grippe

Zur gezielten Behandlung der Grippe stehen antivirale – also gegen Viren wirkende – Stoffe zur Verfügung: Oseltamivir und Zanamivir hemmen die Neuraminidase, eines der Oberflächenmoleküle des Virus. Die Neuraminidase spielt unter anderem eine wichtige Rolle bei der Freisetzung der Viren von einer infizierten Zelle.

Your Photo Today/A1Pix

Jährlich fällig: Die Grippeimpfung

Es existieren wirksame Impfstoffe gegen die Grippe. Der Inhalt wird regelmäßig angepasst, damit er möglichst gut gegen die häufigsten aktuellen Virustypen der Saison schützt. Deshalb und weil die Wirksamkeit der Impfung nicht lange anhält, ist jährlich eine neue Impfung notwendig.

Wegen des sich ständig verändernden Virus kann jedoch keine Impfung hundertprozentig schützen. Um Infektionen vorzubeugen ist es daher außerdem empfehlenswert, auf eine gute Händehygiene zu achten. Bei Erkältungs- und Grippeepidemien kann es sinnvoll sein, auf die Begrüßung per Handschlag zu verzichten, um einer möglichen Ansteckung vorzubeugen.

Die Hände richtig waschen – unser Video zeigt, wie das geht:

If you are in immediate need of help, please contact your local Red Cross or find an open shelter

Seasonal Flu — A contagious respiratory illness caused by influenza (flu) viruses occurring every year. It affects an average of 5 percent to 20 percent of the U.S. population by causing mild to severe illness, and in some instances can lead to death.

Epidemic — The rapid spread of a disease that affects some or many people in a community or region at the same time.

Pandemic — An outbreak of a disease that affects large numbers of people throughout the world and spreads rapidly.

H1N1 Influenza (swine flu) — H1N1 influenza is a respiratory disease of pigs caused by type A influenza viruses that cause regular outbreaks in pigs. People do not normally get H1N1 influenza, but human infections can and do happen. H1N1 influenza viruses have been reported to spread from person-to-person.

Avian Influenza — Commonly known as bird flu, this strain of influenza virus is naturally occurring in birds. Wild birds can carry the virus and may not get sick from it; however, domestic birds may become infected by the virus and often die from it.

Are you considered high risk for flu-related complications?

You are at an increased risk if you are:

  • Age 50 or older
  • Pregnant
  • Living with a chronic medical condition
  • A child, age 6 months and older
  • Living with or caring for anyone at high risk

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    The Symptoms And Treatment
    Of Canine Diabetes Explained

    If You Love Your Dog And Are Worried Canine Diabetes Might Shorten His Or
    Her Life — Relax, Help Is At Hand.

    We can help if you have a problem feeding
    your diabetic dog, need accurate information,
    or want to save money on treatment.

    When your dog is first diagnosed, Vets will often offer good advice on the initial treatment but be aware that much of this advice is quoted from textbooks and very few Vets have experience of treating a diabetic dog in a home environment.

    Whilst there is no outright cure to diabetes in dogs, it can be controlled and our helpful guide give lots of useful information to help you and your pet to lead a near normal life.

    There are three forms of canine diabetes, all of which display very similar symptoms, the most noticeable being:

    1. Your dog has increased urination.
    2. Your dog drinks frequently / excessively.
    3. Your dog begins to lose weight.
    4. Your dog is often tired, lethargic or sleeps more often.

    Note that these symptoms are not exclusive to diabetes, but they are often the earliest signs detectable by owners.

    Increased Urination
    The increased urination is due to excess glucose which the animal is unable to process normally and so tries to get rid of by urinating. This frequent urination causes greater thirst, thus the animal must drink more frequently to replace the lost fluids.

    If the body cannot gain sufficient energy from the food consumed, it will burn stored fat resulting in a loss of body weight and ketones to become present.

    Weight loss in a diabetic dog which eats normally or even one with an increased appetite is not uncommon. Ketones levels in the bloodstream can be tested and treatment, usually dietary, administered. If left untreated this can lead to ketoacidosis which in serious cases can become an emergency condition leading to coma and even death.

    Tired or Lethargic
    Normally active dogs which suddenly show signs of tiredness, no energy and take to sleeping a lot require urgent attention. An appointment should be made with your Vet ASAP to either prove or discount the possibility of diabetes.

    There are three forms of Diabetes in dogs. They are Diabetes Mellitus, Diabetes Insipidus and Gestational Diabetes. Although all three types of Diabetes occur, Diabetes Mellitus is by far the most common. The use of insulin and prescribed food is often the only method available to enable effective control of your dog's diabetes once the disease has taken hold.

    Diabetes Insipidus
    This is an abnormal increase in urine output, fluid intake and often thirst. It causes symptoms such as urinary frequency because the urine output is not concentrated normally and instead of being a yellow color, the urine is pale, colorless or watery in appearance and the measured concentration (osmolality or specific gravity) is low.

    Diabetes Insipidus resembles diabetes mellitus because the symptoms of both diseases are increased urination and thirst. However, in every other respect, including the causes and treatment, the diseases are completely unrelated.

    Diabetes Mellitus in dogs.
    Insulin is produced by the pancreas and helps regulate blood concentrations of glucose. Diabetes Mellitus is a disorder where their bodies are deficient in the production of insulin or unable to use the insulin produced effectively. The symptoms become worse as the disease progresses so the sooner it is diagnosed the better to avoid complications.

    The Symptoms of Diabetes Mellitus in dogs.
    High blood sugar levels (hyperglycemia) develop because the animal’s body is unable to break down and use glucose properly. This inability causes sugar to appear in the urine (glucosuria) that in turn causes an excessive amount of urination (polyuria). To compensate for the increase in urination the dog must drink an excessive amount (polydipsia).

    Gestational Diabetes
    This occurs only in female dogs during pregnancy when her body does not produce enough insulin or cannot use the insulin it produces correctly. Gestational diabetes has the same symptoms as Diabetes Mellitus and is treated similarly with diet control and sometimes with insulin injections.

    The most obvious symptom is that of a normally well house-trained dog urinating in the home for no apparent reason. Sometimes this can be confused with incontinence, particularly with elderly dogs, but there are other conditions, such as a bladder infection, which can display the same symptoms.

    A relatively simple blood test is required to give an accurate diagnosis. Although the same equipment used for human diabetes blood-sugar checking can also suffice, if the tests confirm diabetes a diabetes management program will be required right away.

    The Canine Diabetes Management Guide is an electronic book available
    for Windows, Mac, Linux, Kindle, iPhone and iPad.

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    • headache
    • nausea
    • fever
    • vomiting and
    • flu-like symptoms

    These symptoms can vary depending on the type of plasmodium that caused the infection.

    Plasmodium falciparum normally take 7 to 14 days to show symptoms while Plasmodium vivax and ovale normally take 8 to 14 days (but in some cases can survive for some months in the human horst) and Plasmodium malariae 7 to 30 days.

    These figures are as indication only - the onset of symptoms varies tremendously and people should not try and diagnose themselves by using any time-frame figures as these listed above.

    Symptoms of malaria infection are not always dramatic, and can easily be dismissed as unimportant.

    Symptoms may appear and disappear in phases and may come and go at various time frames. These cyclic symptoms of malaria are caused by the life cycle of the parasites - as they develop, mature, reproduce and are once again released into the blood stream to infect even more blood and liver cells.

    When this happens a high swinging fever can develop, with marked shivering and intense perspiration.

    Further serious complication involving the kidneys and brain can then develop leading to delirium and coma.

    There are cases reported where symptoms of malaria infection developed 12 months after the patient was bitten by a mosquito, as the plasmodia may remain dormant in the liver for a long period.

    Malaria causes a flu-like illness and these would include

    • fever
    • rigors
    • headaches
    • sweating
    • tiredness
    • myalgia (limbs and back)
    • abdominal pain
    • diarrhea
    • loss of appetite
    • orthostatic hypotension
    • nausea
    • slight jaundice
    • cough
    • enlarged liver and spleen (sometimes not palpable)
    • vomiting

    Fever in the first week of travel in a malaria-risk area is unlikely to be malaria; however, any traveler feeling ill should seek immediate medical care.

    Although malaria is unlikely to be the cause, any fever should be promptly evaluated. If you or your child becomes ill with a fever or flu-like illness while traveling in a malaria-risk area and up to 1 year after returning home, seek immediate medical care.

    Tell your health care provider where you have been traveling.

    The normal treatments for malaria infection are drugs based on quinine, or a combination drug therapy known as ACTs, based on artemisinin (which is expensive).

    It is possible, but not very general, to develop a relapsing type of malaria months for even years after being infected by malaria - even if anti-malarial drugs were taken.

    While anti-malarial drugs can prevent symptoms of acute malaria from developing, by suppressing the infection in the bloodstream, they however do not prevent relapses of the infection caused by certain strains of the plasmodium parasite which have a persistent liver phase.

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    Low levels of thyroid increases the risk of developing diabetes

    …Low levels of thyroid hormone in the blood increases the risk of developing type 2 diabetes, especially in people with pre-diabetes, a new study nearly 8,500 people finds….

    Diabetes medicine ‘Liraglutide “Lowers Risk of heart attack, stroke, kidney disease

    Type 2 diabetes affects more than 370 million people worldwide, suggests the Organization World Health Organization. in the United States, more than 29 million people have the disease,…

    Influenza lowers the body’s ability to fight other infections. It can lead to bacterial infections, such as pneumonia, and even death especially in the elderly, children (6–59 months), pregnant women, indigenous people, and people with chronic medical conditions.

    Learn more about influenza, including cause, symptoms, risks, treatment and prevention.

    One of the best ways to prevent seasonal influenza is through yearly immunization because the influenza virus changes each year.

    As part of Alberta's influenza immunization program, Albertans 6 months of age and older are able to receive influenza vaccine, free of charge, at public health clinics, pharmacies and doctor’s offices.

    • About immunization
    • Where to get immunized
    • Contact your local pharmacist or physician for details on vaccine availability

    Alberta Health is offering Albertans one type of influenza vaccine free of charge. This vaccine, called Fluzone, is offered as an injection, contains 4 strains of influenza virus and is a safe and effective vaccine for all ages.

    Having multiple types of vaccines increases the complexity of our immunization program. Offering one type of vaccine to Albertans at mass public clinics, pharmacies and doctor’s offices means we can offer a more efficient program where vaccine is available for everyone across the province when clinics open.

    Alberta Health will not offer FluMist (the nasal spray) this season. In previous years, FluMist had been available for children between the ages of 2 and 17.

    • In 2016, Canada’s National Advisory Committee on Immunization removed its preferential recommendation for FluMist for children 2–17 years of age. The committee concluded that FluMist and injectable vaccines are equally safe and effective for children.

    FLUAD is an influenza vaccine designed to boost the immune response in seniors. This year, FLUAD will not be available at public health clinics. Seniors living in long term care or supportive living will continue to be offered FLUAD free of charge.

    • This aligns with recommendations from the National Advisory Committee on Immunization. The committee recommends either FLUAD or a regular four-strain vaccine for seniors.
    • Some pharmacists may choose to offer FLUAD to Albertans age 65 and older at a cost. Seniors who wish to be immunized with FLUAD can contact their pharmacies for more information.

    • In 2016/17, Canadian estimates on vaccine effectiveness show vaccine was 42% effective against the dominant strain, H3N2.
      • This is slightly lower than in 2015/16 when the vaccine was 50% effective and the dominant strain of influenza was H1N1. Vaccine effectiveness is often lower against H3N2 strains of influenza, so this could explain why the vaccine was less effective.
      • Even with an effectiveness rating of 42%, immunization is the best way for Albertans to protect themselves and others against influenza.

    Vaccine effectiveness varies from year to year but immunization is still the best protection. We do not know how effective this year’s vaccine will be, but we do know that not being immunized offers no protection.

    • Alberta has purchased 1.6 million doses of influenza vaccine for the 2017/18 season. This is enough to immunize 35% of the population.
      • Total cost: $12.1 million.
    • In 2016/17, Alberta Health purchased 1.6 million doses of influenza vaccine.
      • Total cost: $12.7 million
      • 27% of Albertans (roughly 1.1 million people) received the influenza vaccine
      • 64 people died and had lab-confirmed influenza
      • 1,653 Albertans were admitted to hospital with lab-confirmed influenza.
    • Alberta has offered universal influenza immunization free of charge to residents since 2009.
    • The program before 2009 targeted those most at risk of disease and complications.
    • 2016/17 – 27.0% (more influenza data is available on the Alberta Health Services influenza website )
    • 2015/16 – 27.0%
    • 2014/15 – 30.0%
    • 2013/14 – 27.6%
    • 2012/13 – 23.0%
    • 2011/12 – 22.5%
    • 2010/11 – 22.0%

    Every year we hope to see more Albertans get immunized, and we encourage all Albertans age 6 months and older to be immunized when vaccine is available.

    Healthcare workers are strongly encouraged to get immunized. The proportion of health care workers getting vaccinated against influenza in 2016/17 was 63%, compared to 61% in 2015/16.

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    Diabetic ketoacidosis (DKA) is a serious condition that can lead to diabetic coma (passing out for a long time) or even death.

    When your cells don't get the glucose they need for energy, your body begins to burn fat for energy, which produces ketones. Ketones are chemicals that the body creates when it breaks down fat to use for energy. The body does this when it doesn’t have enough insulin to use glucose, the body’s normal source of energy. When ketones build up in the blood, they make it more acidic. They are a warning sign that your diabetes is out of control or that you are getting sick.

    High levels of ketones can poison the body. When levels get too high, you can develop DKA. DKA may happen to anyone with diabetes, though it is rare in people with type 2.

    Treatment for DKA usually takes place in the hospital. But you can help prevent it by learning the warning signs and checking your urine and blood regularly.

    DKA usually develops slowly. But when vomiting occurs, this life-threatening condition can develop in a few hours. Early symptoms include the following:

    • Thirst or a very dry mouth
    • Frequent urination
    • High blood glucose (blood sugar) levels
    • High levels of ketones in the urine

    Then, other symptoms appear:

    • Constantly feeling tired
    • Dry or flushed skin
    • Nausea, vomiting, or abdominal pain
      (Vomiting can be caused by many illnesses, not just ketoacidosis. If vomiting continues for more than 2 hours, contact your health care provider.)
    • Difficulty breathing
    • Fruity odor on breath
    • A hard time paying attention, or confusion

    Ketoacidosis (DKA) is dangerous and serious. If you have any of the above symptoms, contact your health care provider IMMEDIATELY, or go to the nearest emergency room of your local hospital.

    You can detect ketones with a simple urine test using a test strip, similar to a blood testing strip. Ask your health care provider when and how you should test for ketones. Many experts advise to check your urine for ketones when your blood glucose is more than 240 mg/dl.

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      The severity of symptoms varies from one person to another and depends on two factors: how much or little enzymes a person produces; and on the quantity of food consumed.

      The easiest test for a food intolerance is to remove the food from your diet for at least two weeks, see if symptoms improve and then try reintroducing the food (one by one). If symptoms return, an intolerance is likely.

      Lactose intolerance can be tested far more thoroughly using a lactose tolerance test, a hydrogen breath test and a stool acidity test. Your doctor can arrange these and other food intolerance tests if necessary.

      Food intolerance can be managed simply by cutting the food out of your diet. Babies or younger children with a lactose intolerance can be given soya milk instead of cow's milk. Adults may be able to tolerate small amounts of troublesome foods, so may need to experiment to work out what they can eat.

      Supplements of digestive enzymes make life easier. The right enzyme will help break down food consumed that before it caused the symptoms. These enzymes are now available from Below is a list of digestive enzymes to help you understand which enzyme is required to break which food.

      An enzyme is a protein that binds itself to a substance and converts it into another substance or smaller substances. Unless proteins, fats and carbohydrates (sugars) are converted into absorbable components they will remain in the digestive track leading to unpleasant symptoms as a result of their consumption by the bacteria living in our guts. The following table gives a glance for what each enzyme does and where it is produced/found:

      Opiate withdrawal refers to a wide range of symptoms that can occur once opioid intake is interrupted or reduced. The amount, length and intensity of the symptoms vary from person to person. For some individuals, it can be a natural process, and for others, withdrawal can be severe. Opiate withdrawal occurs because it takes time for the body to regulate to no longer having the drug in the system.

      An opioid is synthetic narcotic works similarly to naturally occurring opiates. These opiate-like substances bind to the opioid receptor sites in the brain, spinal cord, and gastrointestinal tract. Once the drugs attach to these receptor sites, they immediately exert their effects. The brain manufactures its own opioids which are responsible for a host of physical responses. Some of these reactions are the decrease of pain, a slower respiratory rate, and sometimes even used to control anxiety or depression. However, the body does not produce the number of opioids needed to manage high levels of pain. Taking prescription or illicit opioids can reduce adverse effects caused by pain, but with an array of dangerous side-effects.

      Opiate withdrawal symptoms can be harsh to surpass if not correctly treated. The fear of going through withdrawal is what keeps many people dependent upon drugs like Heroin and Oxycodone. They don’t want to stop using opiates because they fear a return of pain and withdrawal symptoms that can resemble the worst imaginable flu. Symptoms can affect the individual both physically and emotionally.

      An important fact to keep in mind is that different opioids remain in your system for various lengths of time what can affect the withdrawal syndrome onset. The amount of time your symptoms last depends on a combination of factors including frequency and amount of the use, length of the addiction, as well as individual factors like your health and emotional status.

      Opiate withdrawal symptoms can include

      • Strong cravings
      • Nausea
      • Cramps
      • Sweating
      • Chills
      • Goosebumps
      • Vomiting
      • Diarrhea
      • Shakes
      • Irritation
      • Agitation
      • Anxiety
      • Muscle aches
      • A runny nose
      • Yawning
      • Insomnia
      • Dilated pupils.

      In most cases, these symptoms can be managed by a specialized medical treatment facility Opiate withdrawal can be a long and painful process and very hard to get through. For health compromised patients, untreated and unmonitored withdrawal can lead to unnecessary medical complications such as nausea, rapid heart-rate, elevated blood pressure and dehydration. The consecutive loss of fluids & electrolytes can cause abnormal heart rate and low potassium levels, which can lead to blood circulation issues or even a heart attack.

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      A medically supervised opiate withdrawal in a controlled environment can make the withdrawal much safer and more comfortable. It also provides a much a higher chance of success. In the past, opiate-dependent patients had no choice but to undergo conventional detoxification procedures in nonmedical facilities such as a drug rehab; It caused them to suffer through an unnecessary debilitating and sometimes even dangerous withdrawal syndrome.

      For more information on Medical Opiate Withdrawal Treatment, Call Today 1-800-423-2482

      Natural opiates are alkaloids found in the opium poppy plant, and examples are morphine, codeine, and thebaine. Semi-synthetic opioids are created from natural opiates and include oxycodone, hydrocodone, and hydromorphone. Fully synthetic opioids include fentanyl, methadone, and tramadol.

      People who use opiates for the medical condition can also become physically dependent and require a medical opiate detox. One can take these medications safely over a relatively short period. However, most people become dependent when long-term therapy is needed. This is what makes pain management so tricky. Opiates are prized for their ability to defeat pain. Unfortunately, tolerance, dependence, and addiction can set in, even when the drugs are used correctly. Once this happens, the body needs more of the drug to experience the same effect. This increases the risk of a drug overdose.

      Drug overdose is the leading cause of death in the United States. The American Society of Addiction Medicine (ASAM) reports that 100 people die of a drug overdose daily, and 46 people are due to prescription opioid overdose.

      Many opioid withdrawal treatment programs, often rely on “replacement” or “substitution” medications such as methadone, Suboxone ( Buprenorphine) or Subutex. These medications are also opioids and may prolong the length of the opiate addiction. Eventually, people dependent on these drugs will require detoxification. For some, Medication-Assisted Therapy (MAT) might be safer than street drugs; for others, being completely opioid-free is the best option. Choosing the appropriate medical detox or the best rapid detox center can dictate the quality and efficiency of the opiate withdrawal treatment.

      The Waismann Method ® of rapid detoxification has demonstrated tremendous success in getting patients comfortably and safely through opiate withdrawal. Recognized as the best opiate treatment center in the world, by offering exceptional medical care and individualized assessment.

      If you or a loved one is planning to stop taking opiates and have a fear of the withdrawal symptoms side effects, gives us a call today at 310-205-0808. Let us tell you how we can help manage your symptoms and get you through this challenging phase privately and compassionately.

      Seeking medical help for an opiate addiction will improve your quality of life, your overall health, reduce the risk of accidental overdose and other related complications. Don’t wait another day, seek help now!

      peste clasica, swine fever, varkenspest, peste porcine, Schweinepest, hog cholera

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      Results from a retrospective nursing home study in the United States show influenza has been found to negatively affect functional status in seniors significantly, and has been associated with activities of daily living (ADL) decline. 11*

      * FLUZONE ® High-Dose is not indicated for the prevention of mortality or hospitalization or complications associated with influenza, such as activities of daily living decline (ADL), independence, quality of life or influenza-attributed morbidity and mortality associated with stroke, heart attack, kidney disease and diabetes.

      of flu-related hospitalizations 2

      of flu-related deaths 2

      Canada's National Advisory Committee on Immunization (NACI) considers adults over the age of 65 to be at high risk of influenza-related complications or hospitalization and recommends that all seniors get an influenza vaccine annually. 3

      FLUZONE ® High-Dose influenza vaccine has been shown to be more effective for seniors than FLUZONE ®† , our standard dose influenza vaccine. 12

      FLUZONE ® High-Dose has been shown to have superior efficacy in preventing laboratory-confirmed influenza compared to the FLUZONE ® standard dose vaccine †. In a large multi-centred clinical trial (conducted in US and Canada) FLUZONE ® High-Dose demonstrated a superior relative efficacy of 24.2% (95% CI: 9.7 - 36.5) in preventing influenza illness attributed to any viral type or subtype. The attack rates of laboratory-confirmed influenza-like illness (primary endpoints) were 1.43% in the FLUZONE ® High-Dose arm and 1.89% for the FLUZONE ®† arm. 1 **

      Though it has only been available in Canada since 2015, FLUZONE ® High-Dose is not new. It has been available in the US since 2009, with over 90 million doses distributed to date. 13

      In choosing a vaccine product, it is important to consider the relative burden of influenza disease caused by the various influenza subtypes (i.e., influenza A(H1N1), influenza A(H3N2) and influenza B) in this age group, as well as the efficacy, immunogenicity and safety profile of the available vaccines. 3

      † Fluzone trivalent standard-dose vaccine is not marketed/available in Canada.
      ** The pre-specified statistical superiority criterion for the primary endpoint (lower limit of the 2-sided 95% CI of the vaccine efficacy of FLUZONE ® High-Dose relative to FLUZONE ® >9.1%; p-value against H0: VE ® High-Dose or FLUZONE ® Trivalent. The study was conducted over two influenza seasons (2011-2012 and 2012-2013). FLUZONE ® High-Dose contained 60 μg of HA per strain while FLUZONE ® Trivalent contained 15 μg of HA per strain. The per-protocol analysis set for efficacy assessments included 15,892 FLUZONE ® High-Dose recipients and 15,911 FLUZONE ® Trivalent recipients. The primary endpoint of the study was the occurrence of laboratory-confirmed influenza, defined as a new onset (or exacerbation) of at least one of the following respiratory symptoms: sore throat, cough, sputum production, wheezing, or difficulty breathing; concurrent with at least one of the following systemic signs or symptoms: temperature > 37.2°C, chills, tiredness, headaches or myalgia.

      In the first year of the study, the influenza B component of the vaccine and the majority of influenza B cases were of the Victoria lineage; in the second year, the influenza B component of the vaccine and the majority of influenza B cases were of the Yamagata lineage.

      Contact your Provincial Public Health Unit today to see if FLUZONE ® High-Dose is covered for your 65+ patients.

      • Publicly funded for personal care homes in Manitoba for 65+ 14

      FLUZONE ® High-Dose is indicated for active immunization against influenza caused by the specific strains of influenza virus contained in the vaccine in adults 65 years of age and older. Annual vaccination against influenza using the current vaccine is recommended as immunity declines in the year following vaccination. i

      • Should not be administered to anyone with a history of severe allergic reaction to egg protein or any component of the vaccine or after previous administration of FLUZONE ® High-Dose or a vaccine containing the same components or constituents. ii
      • FLUZONE ® High-Dose is not indicated for persons less than 65 years of age. iii
      • As with any vaccine, immunization with FLUZONE ® High-Dose may not protect 100% of individuals. Protection is limited to those strains of virus from which the vaccine is prepared or against closely related strains. iv
      • Do not administer FLUZONE ® High-Dose by intravascular injection. Do not administer into the buttocks. v
      • Postpone vaccination in case of moderate/severe febrile illness or acute disease. vi
      • Administer FLUZONE ® High-Dose with caution in persons suffering from coagulation disorders or on anticoagulation therapy. vii
      • Immunocompromised persons (whether from disease or treatment) may not elicit the expected immune response. viii
      • Avoid vaccinating persons who are known to have experienced Guillain-Barré syndrome (GBS) within 6 weeks after a previous influenza vaccination. ix

      Consult the product monograph at for important information relating to adverse reactions, drug interactions, and dosing information which have not been discussed in this piece. The product monograph is also available through our medical department. Call us at 1-888-621-1146.

      1. Sanofi Pasteur Limited. FLUZONE ® High-Dose Influenza Virus Vaccine Trivalent Types A and B (Split Virion). Product Monograph. Date of Approval: May 2017. 2. Public Health Agency of Canada (PHAC). FluWatch. May 3 to May 9, 2015. 3. Public Health Agency of Canada (2016). An Advisory Committee Statement (ACS) National Advisory Committee on Immunization (NACI): Canadian Immunization Guide Chapter on Influenza and Statement on Seasonal Influenza Vaccine for 2017-2018. 4. Health Indicator Profile Statistics Canada. (2014). Health indicator profile, annual estimates, by age group and sex, Canada, provinces, territories, health regions (2013 boundaries) and peer groups, *Archived*. Table 105-0501. Retrieved June 12, 2017 from Statistics Canada: 5. Statistics Canada. (2013) Population Projections for Canada (2013 to 2063), Provinces and Territories (2013 to 2038): Section 2 – Results at the Canada level, 2013 to 2063. (Catalogue number 91-520-X). Retrieved June 12, 2017 from Statistics Canada: 6. Grau AJ, et al. Influenza Vaccination Is Associated With a Reduced Risk of Stroke. Stroke. 2005; 36(7):1501-1506. 7. Udell JA. et al. Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis. JAMA. 2013;310(16):1711-1720. 8. Centers for Disease Control and Prevention (CDC). Prevention and Control of Seasonal Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices — United States, 2016–17 Influenza Season. MMWR Recommendations and Reports Vol. 65 No. 5. August 26, 2016. 9. Husein N, et al. Influenza and Pneumococcal Immunization Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Canadian Journal of Diabetes. 2013;37 Supplement 93. 10. Chen C-I, et al. Influenza Vaccination is Associated with Lower Risk of Acute Coronary Syndrome in Elderly Patients with Chronic Kidney Disease. Medicine (Baltimore). 2016;95(5). 11. Gozalo PL, et al. The impact of influenza on functional decline. Am Geriatr Soc. 2012;60(7): 1260–1267. 12. DiazGranados, C.A., et al. (2014). Efficacy of High-Dose versus Standard-Dose influenza Vaccine. New England Journal of Medicine, 371, 635-645 13. Sanofi Pasteur Inc. Data on file. Distribution Letter Fluzone® High-Dose Influenza Vaccine - Doses Distributed. November 16, 2017. 14. Government of Manitoba (2017). Manitoba First in Canada to introduce New Flu Vaccine for Personal Care Home Residents September 5, 2017.

      FLUZONE ® is a trademark of Sanofi Pasteur. Sanofi Pasteur 1755 Steeles Avenue West, Toronto, Ontario M2R 3T4
      © 2017 Sanofi Pasteur Limited. All rights reserved. DIN: 02445646 SPCA.FLHD.17.08.0044 E

      I FLUZONE ® High-Dose Influenza Virus Vaccine Trivalent Types A and B (Split Virion).
      Product Monograph. Date of Approval: May 2017.

      ii Ibid.
      iii Ibid.
      iv Ibid.
      v Ibid.
      vi Ibid.
      vii Ibid.
      viii Ibid.
      ix Ibid.
      ix Ibid.

      Un vaccin à haute dose contre l’influenza conçu spécifiquement pour les personnes de 65 ans et plus 1

      Les adultes de 65 ans et plus souffrent de manière disproportionnée de morbidité et de mortalité associées à l’influenza 2,3. L’immunité diminue avec l’âge 1 . Bien que les personnes âgées affichent le plus haut taux d’immunisation contre l’influenza de tous les groupes d’âge (plus de 60 %) 4, les vaccins sont environ à moitié moins efficaces chez les personnes âgées que chez les adultes en santé, et leur efficacité varie selon les critères d’évaluation et la population à l’étude 3.

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